4-Aminopyrimidine → HCID 11695729, compound

HRID 2246262Notes

Reaction equation

HRID 2246262 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][N:15]=1.[SH:20][C:21]1[N:25]([CH3:26])[CH:24]=[N:23][N:22]=1>>[CH3:26][N:25]1[CH:24]=[N:23][N:22]=[C:21]1[S:20][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:13][C:14]1[CH:19]=[CH:18][N:17]=[CH:16][N:15]=1

Participants

4

Reactant 3

HCID 689584-AminopyrimidineHCID 111738094-Chloro-6-iodoquinazolineHCID 178481306HCID 178481306, compound

Product 1

HCID 11695729HCID 11695729, compound

Procedure

The compound of Example 18 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, 4-aminopyrimidine and 3-mercapto-4-methyl-1,2,4-triazole.

Sources & evidence

ORD record
ord-af2d2a0946b34b72a1a7f34ad753ea20
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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