5-Methylpyrazin-2-amine → HCID 11537593, compound

HRID 2246263Notes

Reaction equation

HRID 2246263 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:19]=[N:18][C:17]([CH3:20])=[CH:16][N:15]=1.[SH:21][C:22]1[N:26]([CH3:27])[CH:25]=[N:24][N:23]=1>>[CH3:20][C:17]1[N:18]=[CH:19][C:14]([NH:13][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([S:21][C:22]4[N:26]([CH3:27])[CH:25]=[N:24][N:23]=4)[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[N:15][CH:16]=1

Participants

4

Reactant 3

HCID 3132155-Methylpyrazin-2-amineHCID 111738094-Chloro-6-iodoquinazolineHCID 178481306HCID 178481306, compound

Product 1

HCID 11537593HCID 11537593, compound

Procedure

The compound of Example 19 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, 2-amino-5-methylpyrazine and 3-mercapto-4-methyl-1,2,4-triazole.

Sources & evidence

ORD record
ord-a34dec74390a49a9a8fb92d9fa5e9ee7
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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