2-Amino-5-chlorothiazole → HCID 11624988, compound

HRID 2246265Notes

Reaction equation

HRID 2246265 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](I)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[S:15][C:16]([Cl:19])=[CH:17][N:18]=1.[SH:20][C:21]1[N:25]([CH3:26])[CH:24]=[N:23][N:22]=1>>[Cl:19][C:16]1[S:15][C:14]([NH:13][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([S:20][C:21]4[N:25]([CH3:26])[CH:24]=[N:23][N:22]=4)[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[N:18][CH:17]=1

Participants

4

Reactant 3

HCID 389422-Amino-5-chlorothiazoleHCID 111738094-Chloro-6-iodoquinazolineHCID 178481306HCID 178481306, compound

Product 1

HCID 11624988HCID 11624988, compound

Procedure

The compound of Example 21 was manufactured by the same method as in Example 1, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-iodo-quinazoline, 2-amino-5-chlorothiazole and 3-mercapto-4-methyl-1,2,4-triazole.

Sources & evidence

ORD record
ord-8dbd3b1eb937456abc09d1ce61e3790f
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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