1,3-Difluoro-2-propanol → HCID 11596268, compound

HRID 2246271Notes

Reaction equation

HRID 2246271 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:13][CH2:14][CH:15](O)[CH2:16][F:17].[F:19][C:20]1[N:25]=[C:24]2[S:26][C:27]([NH2:29])=[N:28][C:23]2=[CH:22][CH:21]=1>>[F:13][CH2:14][CH:15]([CH2:16][F:17])[O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:29][C:27]1[S:26][C:24]2[C:23]([N:28]=1)=[CH:22][CH:21]=[C:20]([F:19])[N:25]=2

Participants

4

Reactant 3

HCID 679851,3-Difluoro-2-propanolHCID 231602734-Chloroquinazolin-6-olHCID 23160371HCID 23160371, compound

Product 1

HCID 11596268HCID 11596268, compound

Procedure

The compound of Example 29 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-hydroxy-quinazoline, 1,3-difluoro-2-propanol and 5-fluoro-thiazolo[5,4-b]pyridin-2-yl-amine.

Sources & evidence

ORD record
ord-db067db5b5744effa69047da6a536785
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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