1,3-Difluoro-2-propanol → HCID 11596537, compound

HRID 2246272Notes

Reaction equation

HRID 2246272 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[F:13][CH2:14][CH:15](O)[CH2:16][F:17].[CH3:19][O:20][C:21]1[N:26]=[C:25]2[S:27][C:28]([NH2:30])=[N:29][C:24]2=[CH:23][CH:22]=1>>[F:13][CH2:14][CH:15]([CH2:16][F:17])[O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:30][C:28]1[S:27][C:25]2[C:24]([N:29]=1)=[CH:23][CH:22]=[C:21]([O:20][CH3:19])[N:26]=2

Participants

4

Reactant 3

HCID 679851,3-Difluoro-2-propanolHCID 28015575-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 11596537HCID 11596537, compound

Procedure

The compound of Example 30 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 4-chloro-6-hydroxy-quinazoline, 1,3-difluoro-2-propanol and 5-methoxy-thiazolo[5,4-b]pyridin-2-yl-amine.

Sources & evidence

ORD record
ord-8dc26e23a11b463698d01354f5b36041
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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