Aminopyrazine → HCID 11622971, compound

HRID 2246278Notes

Reaction equation

HRID 2246278 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1.IC1C=C2C(=CC=1)N=CN=C2NC1SC2C(N=1)=CC=CN=2>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1

Participants

4

Reactant 3

HCID 78747AminopyrazineHCID 111831744-Chloro-6-methoxyquinazolineHCID 23160320HCID 23160320, compound

Product 1

HCID 11622971HCID 11622971, compound

Procedure

The compound of Example 37 was manufactured using 4-chloro-6-methoxy-quinazoline and 2-aminopyrazine by the same method as in Example 1 for the manufacture of (6-iodoquinazolin-4-yl)-thiazolo[5,4-b]pyridin-2-yl-amine, by a similar method thereto or by a combination of such a method with a conventional method.

Sources & evidence

ORD record
ord-4070da856d8d40ca9bca0d3fde2bb40e
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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