5-Methylpyrazin-2-amine → HCID 178430626, compound

HRID 2246282Notes

Reaction equation

HRID 2246282 reaction equation
[SH:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.Cl[C:8]1[C:9]2[N:17]=[C:16](Cl)[CH:15]=[CH:14][C:10]=2[N:11]=[CH:12][N:13]=1.[NH2:19][C:20]1[CH:25]=[N:24][C:23]([CH3:26])=[CH:22][N:21]=1>>[CH3:26][C:23]1[N:24]=[CH:25][C:20]([NH:19][C:8]2[C:9]3[N:17]=[C:16]([S:1][C:2]4[N:6]=[CH:5][NH:4][N:3]=4)[CH:15]=[CH:14][C:10]=3[N:11]=[CH:12][N:13]=2)=[N:21][CH:22]=1

Participants

4

Reactant 3

HCID 3132155-Methylpyrazin-2-amineHCID 105841654,6-Dichloropyrido[3,2-d]pyrimidineHCID 178527894HCID 178527894, compound

Product 1

HCID 178430626HCID 178430626, compound

Procedure

The compound of Example 42 was manufactured by the same method as in Example 31, by a similar method thereto or by a combination of such a method with a conventional method using 3-mercapto-[1,2,4]triazole, 4,6-dichloropyrido-[3,2-d]-pyrimidine and 2-amino-5-methylpyrazine.

Sources & evidence

ORD record
ord-f5aa5e1dc2264d2f8bbfb500e48d77c9
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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