5-Methylpyrazin-2-amine → HCID 11681822, compound

HRID 2246286Notes

Reaction equation

HRID 2246286 reaction equation
[SH:1][C:2]1[CH:6]=[CH:5][N:4]([CH3:7])[N:3]=1.[NH2:8][C:9]1[CH:14]=[N:13][C:12]([CH3:15])=[CH:11][N:10]=1.Cl[C:17]1[C:18]2[N:26]=[C:25](Cl)[CH:24]=[CH:23][C:19]=2[N:20]=[CH:21][N:22]=1>>[CH3:15][C:12]1[N:13]=[CH:14][C:9]([NH:8][C:17]2[C:18]3[N:26]=[C:25]([S:1][C:2]4[CH:6]=[CH:5][N:4]([CH3:7])[N:3]=4)[CH:24]=[CH:23][C:19]=3[N:20]=[CH:21][N:22]=2)=[N:10][CH:11]=1

Participants

4

Reactant 3

HCID 3132155-Methylpyrazin-2-amineHCID 105841654,6-Dichloropyrido[3,2-d]pyrimidineHCID 178480547HCID 178480547, compound

Product 1

HCID 11681822HCID 11681822, compound

Procedure

The compound of Example 46 was manufactured by the same method as in Example 31, by a similar method thereto or by a combination of such a method with a conventional method using 3-mercapto-1-methylpyrazol, 2-amino-5-methylpyrazine and 4,6-dichloropyrido-[3,2-d]pyrimidine.

Sources & evidence

ORD record
ord-c2b8ccb2f35241fca42f299ed14497f7
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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