5-Methylpyrazin-2-amine → HCID 178430625, compound

HRID 2246288Notes

Reaction equation

HRID 2246288 reaction equation
[SH:1][C:2]1[NH:3][CH:4]=[C:5]([CH3:7])[N:6]=1.[NH2:8][C:9]1[CH:14]=[N:13][C:12]([CH3:15])=[CH:11][N:10]=1.Cl[C:17]1[C:18]2[N:26]=[C:25](Cl)[CH:24]=[CH:23][C:19]=2[N:20]=[CH:21][N:22]=1>>[CH3:7][C:5]1[N:6]=[C:2]([S:1][C:25]2[CH:24]=[CH:23][C:19]3[N:20]=[CH:21][N:22]=[C:17]([NH:8][C:9]4[CH:14]=[N:13][C:12]([CH3:15])=[CH:11][N:10]=4)[C:18]=3[N:26]=2)[NH:3][CH:4]=1

Participants

4

Reactant 3

HCID 3132155-Methylpyrazin-2-amineHCID 105841654,6-Dichloropyrido[3,2-d]pyrimidineHCID 178430903HCID 178430903, compound

Product 1

HCID 178430625HCID 178430625, compound

Procedure

The compound of Example 48 was manufactured by the same method as in Example 31, by a similar method thereto or by a combination of such a method with a conventional method using 2-mercapto-4-methylimidazole, 2-amino-5-methylpyrazine and 4,6-dichloro-pyrido[3,2-d]pyrimidine.

Sources & evidence

ORD record
ord-baafde0dd07946ef9b69d850079ff733
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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