2-Amino-5-fluoropyridine → HCID 178505867, compound

HRID 2246289Notes

Reaction equation

HRID 2246289 reaction equation
[SH:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][N:9]=1.Cl[C:16]1[C:17]2[N:25]=[C:24](Cl)[CH:23]=[CH:22][C:18]=2[N:19]=[CH:20][N:21]=1>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([NH:7][C:16]2[C:17]3[N:25]=[C:24]([S:1][C:2]4[N:6]=[CH:5][NH:4][N:3]=4)[CH:23]=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)=[N:9][CH:10]=1

Participants

4

Reactant 3

HCID 27377012-Amino-5-fluoropyridineHCID 105841654,6-Dichloropyrido[3,2-d]pyrimidineHCID 178527894HCID 178527894, compound

Product 1

HCID 178505867HCID 178505867, compound

Procedure

The compound of Example 50 was manufactured by the same method as in Example 31, by a similar method thereto or by a combination of such a method with a conventional method using 3-mercapto-[1,2,4]triazole, 2-amino-5-fluoropyridine and 4,6-dichloro-pyrido[3,2-d]pyrimidine.

Sources & evidence

ORD record
ord-79f777cc69714f359cea37c915adc4c6
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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