Aminopyrazine → HCID 178420799, compound

HRID 2246299Notes

Reaction equation

HRID 2246299 reaction equation
[SH:1][C:2]1[NH:6][CH:5]=[N:4][N:3]=1.[NH2:7][C:8]1[CH:13]=[N:12][CH:11]=[CH:10][N:9]=1.Cl[C:15]1[C:16]2[N:24]=[C:23](Cl)[CH:22]=[CH:21][C:17]=2[N:18]=[CH:19][N:20]=1>>[N:9]1[CH:10]=[CH:11][N:12]=[CH:13][C:8]=1[NH:7][C:15]1[C:16]2[N:24]=[C:23]([S:1][C:2]3[NH:6][CH:5]=[N:4][N:3]=3)[CH:22]=[CH:21][C:17]=2[N:18]=[CH:19][N:20]=1

Participants

4

Reactant 3

HCID 78747AminopyrazineHCID 105841654,6-Dichloropyrido[3,2-d]pyrimidineHCID 178527972HCID 178527972, compound

Product 1

HCID 178420799HCID 178420799, compound

Procedure

The compound of Example 64 was manufactured by the same method as in Example 31, by a similar method thereto or by a combination of such a method with a conventional method using 3-mercapto-4H-[1,2,4]triazole, 2-amino-pyrazine and 4,6-dichloro-pyrido[3,2-d]pyrimidine.

Sources & evidence

ORD record
ord-6614217ec9444116be1f4cc389a8e8b4
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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