2-Chloronicotinonitrile → HCID 11582048, compound

HRID 2246303Notes

Reaction equation

HRID 2246303 reaction equation
[C:1]([C:3]1[C:4](Cl)=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[N:10]1[C:18]2[C:13](=[N:14][CH:15]=[CH:16][CH:17]=2)[S:12][C:11]=1[NH2:19].Cl[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([OH:31])[CH:29]=2)[N:24]=[CH:23][N:22]=1>>[C:1]([C:3]1[C:4]([O:31][C:28]2[CH:29]=[C:30]3[C:25](=[CH:26][CH:27]=2)[N:24]=[CH:23][N:22]=[C:21]3[NH:19][C:11]2[S:12][C:13]3[C:18]([N:10]=2)=[CH:17][CH:16]=[CH:15][N:14]=3)=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

4

Reactant 3

HCID 810792-ChloronicotinonitrileHCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 11582048HCID 11582048, compound

Procedure

The compound of Example 80 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 3-cyano-2-chloropyridine, thiazolo[5,4-b]pyridin-2-yl-amine and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-069c4e984cd34560ab083b1ac0a66c4a
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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