2-Hydroxy-N-methylacetamide → HCID 11494342, compound

HRID 2246306Notes

Reaction equation

HRID 2246306 reaction equation
[OH:1][CH2:2][C:3]([NH:5][CH3:6])=[O:4].[N:7]1[C:15]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[S:9][C:8]=1[NH2:16].Cl[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25](O)[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[CH3:6][NH:5][C:3]([CH2:2][O:1][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][N:19]=[C:18]2[NH:16][C:8]1[S:9][C:10]2[C:15]([N:7]=1)=[CH:14][CH:13]=[CH:12][N:11]=2)=[O:4]

Participants

4

Reactant 3

HCID 2235792-Hydroxy-N-methylacetamideHCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 11494342HCID 11494342, compound

Procedure

The compound of Example 84 was manufactured by the same method as in Example 22, by a similar method thereto or by a combination of such a method with a conventional method using 2-hydroxy-N-methyl-acetamide, thiazolo[5,4-b]pyridin-2-yl-amine and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-4d443cd51cd7426082ff557841cb52cb
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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