5-Amino-3-methyl-1,2,4-thiadiazole → HCID 11696411, compound

HRID 2246310Notes

Reaction equation

HRID 2246310 reaction equation
F[C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[S:15][N:14]=[C:13]([CH3:16])[N:12]=1.Cl[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([OH:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[F:8][C:7]1[C:2]([O:28][C:25]2[CH:26]=[C:27]3[C:22](=[CH:23][CH:24]=2)[N:21]=[CH:20][N:19]=[C:18]3[NH:10][C:11]2[S:15][N:14]=[C:13]([CH3:16])[N:12]=2)=[N:3][CH:4]=[C:5]([F:9])[CH:6]=1

Participants

4

Reactant 3

HCID 3506395-Amino-3-methyl-1,2,4-thiadiazoleHCID 27832872,3,5-TrifluoropyridineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 11696411HCID 11696411, compound

Procedure

The compound of Example 90 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,3,5-trifluoropyridine, 5-amino-3-methyl[1,2,4]thiadiazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-9615a2a6e73d4f4a954c5e9972a06035
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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