5-Amino-3-methyl-1,2,4-thiadiazole → HCID 11647741, compound

HRID 2246313Notes

Reaction equation

HRID 2246313 reaction equation
F[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[N:13]=[C:12]([CH3:14])[O:11][N:10]=1.[NH2:15][C:16]1[S:20][N:19]=[C:18]([CH3:21])[N:17]=1.Cl[C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[C:30]([OH:33])[CH:31]=2)[N:26]=[CH:25][N:24]=1>>[F:8][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([C:9]2[N:13]=[C:12]([CH3:14])[O:11][N:10]=2)[C:2]=1[O:33][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[N:26]=[CH:25][N:24]=[C:23]2[NH:15][C:16]1[S:20][N:19]=[C:18]([CH3:21])[N:17]=1

Participants

4

Reactant 3

HCID 3506395-Amino-3-methyl-1,2,4-thiadiazoleHCID 231602734-Chloroquinazolin-6-olHCID 23160296HCID 23160296, compound

Product 1

HCID 11647741HCID 11647741, compound

Procedure

The compound of Example 93 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 3-(2,3-difluorophenyl)-5-methyl-1,2,4-oxdiazole, 5-amino-3-methyl-[1,2,4]thiadiazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-6c528c22e2e04a1ab3cf9ecaae7d15be
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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