1-ethyl-1H-pyrazol-3-amine → HCID 11690454, compound

HRID 2246316Notes

Reaction equation

HRID 2246316 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH3:11])(=[O:10])=[O:9])[C:3]=1F.[NH2:13][C:14]1[CH:18]=[CH:17][N:16]([CH2:19][CH3:20])[N:15]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([OH:32])[CH:30]=2)[N:25]=[CH:24][N:23]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH3:11])(=[O:10])=[O:9])[C:3]=1[O:32][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][CH:28]=1)[N:25]=[CH:24][N:23]=[C:22]2[NH:13][C:14]1[CH:18]=[CH:17][N:16]([CH2:19][CH3:20])[N:15]=1

Participants

4

Reactant 3

HCID 121981091-ethyl-1H-pyrazol-3-amineHCID 22747447HCID 22747447, compoundHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 11690454HCID 11690454, compound

Procedure

The compound of Example 96 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2-difluoro-3-methanesulfonylbenzene, 3-amino-1-ethyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-d7bdee2449654964843f58c2eacc5020
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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