1-Methyl-3-aminopyrazole → HCID 11612022, compound

HRID 2246318Notes

Reaction equation

HRID 2246318 reaction equation
[Cl:1][C:2]1[C:3](F)=[C:4]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[NH2:14][C:15]1[CH:19]=[CH:18][N:17]([CH3:20])[N:16]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([OH:32])[CH:30]=2)[N:25]=[CH:24][N:23]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[C:3]=1[O:32][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][CH:28]=1)[N:25]=[CH:24][N:23]=[C:22]2[NH:14][C:15]1[CH:19]=[CH:18][N:17]([CH3:20])[N:16]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-olHCID 23160310N-(3-Chloro-2-fluorophenyl)methanesulfonamide

Product 1

HCID 11612022HCID 11612022, compound

Procedure

The compound of Example 98 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using N-(3-chloro-2-fluorophenyl)methanesulfonamide, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-a9de0064af5d41f2a67982037794dde5
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

Loading…