Benzylamine → 1-benzyl-3-ethylthiourea

HRID 224632Notes

Reaction equation

HRID 224632 reaction equation
[CH2:1]([N:3]=[C:4]=[S:5])[CH3:2].[CH2:6]([NH2:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1C=CC=CC=1>[CH2:1]([NH:3][C:4]([NH:13][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[S:5])[CH3:2]

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 10966Ethyl isothiocyanate

Product 1

HCID 37688051-benzyl-3-ethylthioureaYield 94.4%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a mixture of 1.74 grams (0.02 mole) of ethyl isothiocyanate and 25 milliliters of benzene was added 2.14 grams (0.02 mole) of benzylamine. The temperature rose from 25° C. to 41° C. The reaction mixture was then refluxed on a steam bath for about 20 minutes to bring the reaction to completion. The mixture was evaporated under vacuum to give 3.67 grams of 1-ethyl-3-benzyl thiourea.

Workup

  1. customrose from 25° C. to 41° C
  2. temperatureThe reaction mixture was then refluxed on a steam bath for about 20 minutes
  3. customthe reaction to completion
  4. customThe mixture was evaporated under vacuum

Sources & evidence

ORD record
ord-51c201b4de8b4f15908368d8052cc0ad
Source dataset
uspto-grants-1980_11
Patent number
US04233318

Reaction notes

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