2,3-Difluorobenzonitrile → HCID 23160346, compound

HRID 2246320Notes

Reaction equation

HRID 2246320 reaction equation
F[C:2]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:11][CH:12]1[CH2:17][NH:16][CH:15]([CH3:18])[CH2:14][NH:13]1.Cl[C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([OH:30])[CH:28]=2)[N:23]=[CH:22][N:21]=1>>[F:10][C:9]1[C:2]([O:30][C:27]2[CH:28]=[C:29]3[C:24](=[CH:25][CH:26]=2)[N:23]=[CH:22][N:21]=[C:20]3[NH:11][C:12]2[CH:17]=[N:16][C:15]([CH3:18])=[CH:14][N:13]=2)=[C:3]([CH:6]=[CH:7][CH:8]=1)[C:4]#[N:5]

Participants

4

Reactant 3

HCID 889352,3-DifluorobenzonitrileHCID 231602734-Chloroquinazolin-6-olHCID 23160305HCID 23160305, compound

Product 1

HCID 23160346HCID 23160346, compound

Procedure

The compound of Example 157 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,3-difluorobenzonitrile, 2-amino-5-methylpiperazine and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-7b0ad820428f4f2caf39b16ebc54852f
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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