1-Methyl-3-aminopyrazole → HCID 23160334, compound

HRID 2246323Notes

Reaction equation

HRID 2246323 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:14]=[CH:13][N:12]([CH3:15])[N:11]=1.Cl[C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([OH:27])[CH:25]=2)[N:20]=[CH:19][N:18]=1>>[F:8][C:5]1[CH:6]=[CH:7][C:2]([O:27][C:24]2[CH:25]=[C:26]3[C:21](=[CH:22][CH:23]=2)[N:20]=[CH:19][N:18]=[C:17]3[NH:9][C:10]2[CH:14]=[CH:13][N:12]([CH3:15])[N:11]=2)=[N:3][CH:4]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 27628712,5-DifluoropyridineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160334HCID 23160334, compound

Procedure

The compound of Example 115 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,5-difluoropyridine, 3-amino-1-methyl-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-bfccee691823420cb51eee02ffd22f11
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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