2,3-Dichloropyridine → HCID 178478201, compound

HRID 2246326Notes

Reaction equation

HRID 2246326 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[NH:14][CH:13]=[N:12][N:11]=1.Cl[C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([OH:26])[CH:24]=2)[N:19]=[CH:18][N:17]=1>>[Cl:8][C:7]1[C:2]([O:26][C:23]2[CH:24]=[C:25]3[C:20](=[CH:21][CH:22]=2)[N:19]=[CH:18][N:17]=[C:16]3[NH:9][C:10]2[NH:14][CH:13]=[N:12][N:11]=2)=[N:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 169882,3-DichloropyridineHCID 231602734-Chloroquinazolin-6-olHCID 178509196HCID 178509196, compound

Product 1

HCID 178478201HCID 178478201, compound

Procedure

The compound of Example 118 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,3-dichloropyridine, 3-amino-4H-[1,2,4]triazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-992feba3db3a4db2b39441986a0e5e3c
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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