1-Methyl-3-aminopyrazole → HCID 23160342, compound

HRID 2246330Notes

Reaction equation

HRID 2246330 reaction equation
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:12][C:13]1[CH:17]=[CH:16][N:15]([CH3:18])[N:14]=1.Cl[C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([OH:30])[CH:28]=2)[N:23]=[CH:22][N:21]=1>>[CH3:18][N:15]1[CH:16]=[CH:17][C:13]([NH:12][C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:30][C:2]4[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=4)[CH:28]=3)[N:23]=[CH:22][N:21]=2)=[N:14]1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160342HCID 23160342, compound

Procedure

The compound of Example 123 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2-chloro-3-(trifluoromethyl)pyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-52a7a5ffb373486ba755680ec13c3a58
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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