1-Methyl-3-aminopyrazole → HCID 23160263, compound

HRID 2246331Notes

Reaction equation

HRID 2246331 reaction equation
Cl[C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1.Cl[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([OH:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[CH3:16][N:13]1[CH:14]=[CH:15][C:11]([NH:10][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([O:28][C:2]4[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][N:3]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)=[N:12]1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 2763647(2-Chloropyridin-3-yl)methanolHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160263HCID 23160263, compound

Procedure

The compound of Example 124 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2-chloro-3-hydroxymethylpyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-9efed85593bf4cc1b2f9e6ace4298dc6
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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