1-Methyl-3-aminopyrazole → HCID 23160265, compound

HRID 2246333Notes

Reaction equation

HRID 2246333 reaction equation
[C:1]([C:4]1[C:5](Cl)=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[NH2:11][C:12]1[CH:16]=[CH:15][N:14]([CH3:17])[N:13]=1.Cl[C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([OH:29])[CH:27]=2)[N:22]=[CH:21][N:20]=1>>[CH3:17][N:14]1[CH:15]=[CH:16][C:12]([NH:11][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][C:5]4[C:4]([C:1](=[O:3])[CH3:2])=[CH:9][CH:8]=[CH:7][N:6]=4)[CH:27]=3)[N:22]=[CH:21][N:20]=2)=[N:13]1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 109426973-Acetyl-2-chloropyridineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160265HCID 23160265, compound

Procedure

The compound of Example 126 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 3-acetyl-2-chloropyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-9d3d9dfa43524e8696883ff3787daef5
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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