1-Methyl-3-aminopyrazole → HCID 23160268, compound

HRID 2246336Notes

Reaction equation

HRID 2246336 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][F:9])[C:3]=1F.[NH2:11][C:12]1[CH:16]=[CH:15][N:14]([CH3:17])[N:13]=1.Cl[C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([OH:29])[CH:27]=2)[N:22]=[CH:21][N:20]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][F:9])[C:3]=1[O:29][C:26]1[CH:27]=[C:28]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][N:20]=[C:19]2[NH:11][C:12]1[CH:16]=[CH:15][N:14]([CH3:17])[N:13]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 6432291HCID 6432291, compoundHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160268HCID 23160268, compound

Procedure

The compound of Example 130 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2-difluoro-3-(fluoromethyl)benzene, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-3229961e82c941478b913cd3e0984211
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

Loading…