1-Methyl-3-aminopyrazole → HCID 23160333, compound

HRID 2246337Notes

Reaction equation

HRID 2246337 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][C:3]=1[Cl:10].[NH2:11][C:12]1[CH:16]=[CH:15][N:14]([CH3:17])[N:13]=1.Cl[C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([OH:29])[CH:27]=2)[N:22]=[CH:21][N:20]=1>>[Cl:10][C:3]1[CH:4]=[C:5]([CH2:8][OH:9])[CH:6]=[CH:7][C:2]=1[O:29][C:26]1[CH:27]=[C:28]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][N:20]=[C:19]2[NH:11][C:12]1[CH:16]=[CH:15][N:14]([CH3:17])[N:13]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 27736073-Chloro-4-fluorobenzyl alcoholHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160333HCID 23160333, compound

Procedure

The compound of Example 131 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 4-fluoro-3-chlorobenzenemethanol, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-267dc44657f640df9c2cb85eef42be40
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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