5-Amino-3-methyl-1,2,4-thiadiazole → HCID 23160277, compound

HRID 2246338Notes

Reaction equation

HRID 2246338 reaction equation
F[C:2]1[CH:11]=[CH:10][C:9]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[NH2:16][C:17]1[S:21][N:20]=[C:19]([CH3:22])[N:18]=1.Cl[C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([OH:34])[CH:32]=2)[N:27]=[CH:26][N:25]=1>>[CH3:15][S:12]([C:9]1[CH:10]=[CH:11][C:2]([O:34][C:31]2[CH:32]=[C:33]3[C:28](=[CH:29][CH:30]=2)[N:27]=[CH:26][N:25]=[C:24]3[NH:16][C:17]2[S:21][N:20]=[C:19]([CH3:22])[N:18]=2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5])(=[O:14])=[O:13]

Participants

4

Reactant 3

HCID 3506395-Amino-3-methyl-1,2,4-thiadiazoleHCID 231602734-Chloroquinazolin-6-olHCID 23160357HCID 23160357, compound

Product 1

HCID 23160277HCID 23160277, compound

Procedure

The compound of Example 132 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using methyl 2-fluoro-5-methylsulfonylbenzoate, 5-amino-3-methyl-[1,2,4]thiadiazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-c55f349aee6f4ae1abf989a245e57d59
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

Loading…