1-Methyl-3-aminopyrazole → HCID 23160335, compound

HRID 2246340Notes

Reaction equation

HRID 2246340 reaction equation
F[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[NH2:12][C:13]1[CH:17]=[CH:16][N:15]([CH3:18])[N:14]=1.Cl[C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([OH:30])[CH:28]=2)[N:23]=[CH:22][N:21]=1>>[F:8][C:7]1[C:2]([O:30][C:27]2[CH:28]=[C:29]3[C:24](=[CH:25][CH:26]=2)[N:23]=[CH:22][N:21]=[C:20]3[NH:12][C:13]2[CH:17]=[CH:16][N:15]([CH3:18])[N:14]=2)=[C:3]([C:9](=[O:11])[CH3:10])[CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 5195502',3'-DifluoroacetophenoneHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160335HCID 23160335, compound

Procedure

The compound of Example 134 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1-(2,3-difluoro phenyl)ethanone, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-9a3df25d02b94e6982c28b48e1bd0d48
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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