2,3-Dichloropyridine → HCID 23160325, compound

HRID 2246341Notes

Reaction equation

HRID 2246341 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:14]=[CH:13][N:12]([CH:15]([F:17])[F:16])[N:11]=1.Cl[C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([OH:29])[CH:27]=2)[N:22]=[CH:21][N:20]=1>>[Cl:8][C:7]1[C:2]([O:29][C:26]2[CH:27]=[C:28]3[C:23](=[CH:24][CH:25]=2)[N:22]=[CH:21][N:20]=[C:19]3[NH:9][C:10]2[CH:14]=[CH:13][N:12]([CH:15]([F:17])[F:16])[N:11]=2)=[N:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 169882,3-DichloropyridineHCID 231602734-Chloroquinazolin-6-olHCID 23160373HCID 23160373, compound

Product 1

HCID 23160325HCID 23160325, compound

Procedure

The compound of Example 135 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,3-dichloropyridine, 3-amino-1-(difluoromethyl)-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-0986ff8e8e11416f9a8e142c1fa0c628
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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