5-Amino-3-methyl-1,2,4-thiadiazole → HCID 23160284, compound

HRID 2246342Notes

Reaction equation

HRID 2246342 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10].[NH2:15][C:16]1[S:20][N:19]=[C:18]([CH3:21])[N:17]=1.Cl[C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[C:30]([OH:33])[CH:31]=2)[N:26]=[CH:25][N:24]=1>>[Cl:8][C:7]1[C:2]([O:33][C:30]2[CH:31]=[C:32]3[C:27](=[CH:28][CH:29]=2)[N:26]=[CH:25][N:24]=[C:23]3[NH:15][C:16]2[S:20][N:19]=[C:18]([CH3:21])[N:17]=2)=[C:3]([S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10])[CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 3506395-Amino-3-methyl-1,2,4-thiadiazoleHCID 174445642,3-Dichloro-N,N-dimethylbenzenesulfonamideHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160284HCID 23160284, compound

Procedure

The compound of Example 136 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,3-dichloro-N,N-dimethyl-benzenesulfonamide, 5-amino-3-methyl-[1,2,4]thiadiazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-9ceb9bddd1864cf691e1836fbda64b80
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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