5-Amino-3-methyl-1,2,4-thiadiazole → HCID 23160326, compound

HRID 2246343Notes

Reaction equation

HRID 2246343 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])[C:3]=1Cl.[NH2:14][C:15]1[S:19][N:18]=[C:17]([CH3:20])[N:16]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([OH:32])[CH:30]=2)[N:25]=[CH:24][N:23]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])[C:3]=1[O:32][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][CH:28]=1)[N:25]=[CH:24][N:23]=[C:22]2[NH:14][C:15]1[S:19][N:18]=[C:17]([CH3:20])[N:16]=1

Participants

4

Reactant 3

HCID 3506395-Amino-3-methyl-1,2,4-thiadiazoleHCID 231602734-Chloroquinazolin-6-olHCID 23160381HCID 23160381, compound

Product 1

HCID 23160326HCID 23160326, compound

Procedure

The compound of Example 137 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2-dichloro-3-(ethanesulfonyl)benzene, 5-amino-3-methyl-[1,2,4]thiadiazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-13fa7042fee24f538d5416640fe334de
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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