1-Methyl-3-aminopyrazole → HCID 23160318, compound

HRID 2246344Notes

Reaction equation

HRID 2246344 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH:11]2[CH2:13][CH2:12]2)(=[O:10])=[O:9])[C:3]=1Cl.[NH2:15][C:16]1[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=1.Cl[C:23]1[C:32]2[C:27](=[CH:28][CH:29]=[C:30]([OH:33])[CH:31]=2)[N:26]=[CH:25][N:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH:11]2[CH2:13][CH2:12]2)(=[O:10])=[O:9])[C:3]=1[O:33][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[N:26]=[CH:25][N:24]=[C:23]2[NH:15][C:16]1[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-olHCID 23160283HCID 23160283, compound

Product 1

HCID 23160318HCID 23160318, compound

Procedure

The compound of Example 139 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2-dichloro-3-(cyclopropylsulfonyl)benzene, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-90c3a46a5dd84b1e8899a8ba8d15f925
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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