2-Amino-5-chloropyrazine → HCID 23160285, compound

HRID 2246347Notes

Reaction equation

HRID 2246347 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([CH3:11])(=[O:10])=[O:9])[C:3]=1F.[NH2:13][C:14]1[CH:19]=[N:18][C:17]([Cl:20])=[CH:16][N:15]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([OH:32])[CH:30]=2)[N:25]=[CH:24][N:23]=1>>[Cl:20][C:17]1[N:18]=[CH:19][C:14]([NH:13][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[C:29]([O:32][C:3]4[C:4]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])[CH:30]=3)[N:25]=[CH:24][N:23]=2)=[N:15][CH:16]=1

Participants

4

Reactant 3

HCID 128084192-Amino-5-chloropyrazineHCID 22747447HCID 22747447, compoundHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160285HCID 23160285, compound

Procedure

The compound of Example 144 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2-difluoro-3-(methylsulfonyl)benzene, 2-amino-5-chloropyrazine and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-0c8e9dcf96a34b58b0add486d6e567de
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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