1-Methyl-3-aminopyrazole → HCID 23160327, compound

HRID 2246348Notes

Reaction equation

HRID 2246348 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][OH:11])[CH:5]=[C:6]([F:9])[C:7]=1F.[NH2:12][C:13]1[CH:17]=[CH:16][N:15]([CH3:18])[N:14]=1.Cl[C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([OH:30])[CH:28]=2)[N:23]=[CH:22][N:21]=1>>[F:9][C:6]1[CH:5]=[C:4]([CH2:10][OH:11])[CH:3]=[C:2]([F:1])[C:7]=1[O:30][C:27]1[CH:28]=[C:29]2[C:24](=[CH:25][CH:26]=1)[N:23]=[CH:22][N:21]=[C:20]2[NH:12][C:13]1[CH:17]=[CH:16][N:15]([CH3:18])[N:14]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 27770403,4,5-Trifluorobenzyl alcoholHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160327HCID 23160327, compound

Procedure

The compound of Example 145 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 3,4,5-trifluoro-benzenemethanol, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-cbf17554b76a473b8e144b4613d18318
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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