1,2,3-Trifluorobenzene → HCID 23160266, compound

HRID 2246350Notes

Reaction equation

HRID 2246350 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1F.[NH2:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1.Cl[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([OH:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[O:28][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[N:21]=[CH:20][N:19]=[C:18]2[NH:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1

Participants

4

Reactant 3

HCID 151471,2,3-TrifluorobenzeneHCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160266HCID 23160266, compound

Procedure

The compound of Example 148 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 1,2,3-trifluorobenzene, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-bac0e50a817145e198e7ad169002c832
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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