1-Methyl-3-aminopyrazole → HCID 23160366, compound

HRID 2246352Notes

Reaction equation

HRID 2246352 reaction equation
F[C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:12][F:13].[NH2:14][C:15]1[CH:19]=[CH:18][N:17]([CH3:20])[N:16]=1.Cl[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29]([OH:32])[CH:30]=2)[N:25]=[CH:24][N:23]=1>>[F:13][CH2:12][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])[C:2]=1[O:32][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][CH:28]=1)[N:25]=[CH:24][N:23]=[C:22]2[NH:14][C:15]1[CH:19]=[CH:18][N:17]([CH3:20])[N:16]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-olHCID 23160311HCID 23160311, compound

Product 1

HCID 23160366HCID 23160366, compound

Procedure

The compound of Example 150 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2-fluoro-1-(fluoromethyl)-3-(methylsulfonyl)benzene, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-570284f3a182422382ebcc3bb8ed96e6
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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