1-Methyl-3-aminopyrazole → HCID 23160347, compound

HRID 2246355Notes

Reaction equation

HRID 2246355 reaction equation
Cl[C:2]1[C:7]([F:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1.Cl[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([OH:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[Cl:9][C:5]1[CH:6]=[C:7]([F:8])[C:2]([O:28][C:25]2[CH:26]=[C:27]3[C:22](=[CH:23][CH:24]=2)[N:21]=[CH:20][N:19]=[C:18]3[NH:10][C:11]2[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=2)=[N:3][CH:4]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 109648772,5-Dichloro-3-fluoropyridineHCID 231602734-Chloroquinazolin-6-ol

Product 1

HCID 23160347HCID 23160347, compound

Procedure

The compound of Example 154 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2,5-dichloro-3-fluoropyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-c97f592a498349b9a3394b0be818b750
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

Loading…