1-Methyl-3-aminopyrazole → HCID 23160272, compound

HRID 2246357Notes

Reaction equation

HRID 2246357 reaction equation
F[C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:12].[NH2:13][C:14]1[CH:18]=[CH:17][N:16]([CH3:19])[N:15]=1.Cl[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([OH:31])[CH:29]=2)[N:24]=[CH:23][N:22]=1>>[CH3:12][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])[C:2]=1[O:31][C:28]1[CH:29]=[C:30]2[C:25](=[CH:26][CH:27]=1)[N:24]=[CH:23][N:22]=[C:21]2[NH:13][C:14]1[CH:18]=[CH:17][N:16]([CH3:19])[N:15]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 231602734-Chloroquinazolin-6-olHCID 231603612-Fluoro-1-(methanesulfonyl)-3-methylbenzene

Product 1

HCID 23160272HCID 23160272, compound

Procedure

The compound of Example 156 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2-fluoro-1-methyl-3-(methylsulfonyl)benzene, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.

Sources & evidence

ORD record
ord-6c62f3302bac4c7cbccf86131c4de1ec
Source dataset
uspto-grants-2010_03
Patent number
US07687502B2

Reaction notes

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