(3-Trifluoromethylphenyl)urea → HCID 58674220, compound

Participants

Reaction Steps

200 mg (0.98 mmol) N-[3-(trifluoromethyl)phenyl]urea, 129 mg (0.98 mmol) 4-cyanobenzaldehyde, 92 mg (0.49 mmol) (1S)-2-methoxy-1-methyl-2-oxoethyl 3-oxobutanoate, and 295 mg polyphosphoric acid ethyl ester are suspended in 3 ml of THF. The mixture is stirred at reflux for 18 hours. After cooling down to room temperature, the solvent is removed in vacuo and the residue is purified by column chromatography on silica with cyclohexane/ethyl acetate as eluent. A mixture of diastereoisomers is obtained.

Provenance & Evidence