Hydrochloric Acid → HCID 58674269, compound

Participants

Reaction Steps

400 mg (1.97 mmol) N-[3-(trifluoromethyl)phenyl]urea, 199 mg (1.51 mmol) 4-cyanobenzaldehyde and 100 mg (1.51 mmol) malononitrile are suspended in 2 ml of THE, and catalytic amounts of concentrated hydrochloric acid are added. The mixture is stirred at reflux for 18 hours. After cooling down to room temperature, the solvent is removed in vacuo and the residue is purified by column chromatography on silica with dichloromethane/methanol as eluent.

Provenance & Evidence