(3-Trifluoromethylphenyl)urea → HCID 68431415, compound

Participants

Reaction Steps

9.87 g (48.3 mmol) N-[3-(trifluoromethyl)phenyl]urea, 12.68 g (96.68 mmol) 4-cyanobenzaldehyde, 15 g (96.68 mmol) (2-cyanoethyl) 3-oxobutanoate and 37.5 g polyphosphoric acid ethyl ester are suspended in 250 ml of THF. The mixture is stirred at reflux for 18 hours. After cooling down to room temperature, the solvent is removed in vacuo and the residue is purified by column chromatography on silica with cyclohexane/ethyl acetate as eluent.

Provenance & Evidence