Potassium Carbonate → HCID 58938125, compound

Participants

Reaction Conditions

Reaction Steps

A stirring suspension of 4-amino-6-chloro-3-nitro-pyridine-2-carbonitrile (1.0 g, 5.04 mmol), 3-(trifluoromethyl)phenyl boronic acid (1148 mg, 6.04 mmol) and potassium carbonate (2.08 g, 15.1 mmol) in THF (16 ml) was degassed with nitrogen before the addition of palladium tetrakistriphenylphosphine (582 mg, 0.50 mmol). The resulting suspension was heated to 150° C. for 5 minutes using the ‘Creator’ microwave. The reaction mixture was filtered through celite and concentrated in vacuo. The residual brown oil was columned on silica gel using dichloromethane as eluant to give the title compound as a yellow solid (300 mg).

Provenance & Evidence