1H-1,2,4-Triazole → HCID 25260770, compound

Participants

Reaction Steps

A solution of Compound 11 (50 mg), 1,2,4-triazole (31 mg) and NaHCO3 (15 mg) in dry N,N-dimethylformamide (1 mL) was heated at 70° C. for 5 hours under argon. The N,N-dimethylformamide was removed from the reaction mixture under vacuum and the residue was directly eluted on a silica gel column using 4% ethanol in dichloromethane to obtain the required product in 61% yield (30 mg).

Provenance & Evidence