Sodium Azide → HCID 25260924, compound

Participants

Reaction Steps

A solution of Compound 19 (1.96 g) and sodium azide (725 mg) in N,N-dimethylformamide (15 mL) was heated at 80° C. for 3 hours. The N,N-dimethylformamide was concentrated under reduced pressure and the residue was partitioned between chloroform (25 mL) and 1 N HCl (10 mL). The organic layer was separated, dried and concentrated to obtain the crude product and was purified by eluting on a silica gel column using 1-2% ethanol in dichloromethane to yield 95% of the required product (1.75 g).

Provenance & Evidence