Pyridine → HCID 25261082, compound

Participants

Reaction Steps

To a solution of Compound 21 (150 mg) in dichloromethane (2 mL) at 0° C., trifluoromethanesulfonic anhydride (80 μL) and pyridine were added and stirred at room temperature for 2 hours. Solvents were dried under vacuum and the crude residue was finally shaken between chloroform (2×10 mL) and 1 N HCl (5 mL). The collective organic layer was dried, evaporated and purified on a silica gel column using 2% ethanol in dichloromethane to obtain 96% of the required product (140 mg).

Provenance & Evidence