2-Mercaptoethanol → (4S)-4-ethyl-4-hydroxy-11-{2-[(2-hydroxy-ethylsulfanylmethyl)-dimethyl-silanyl]-ethyl}-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

Participants

Role	Name	HCID	Charge
Reactant	2-Mercaptoethanol	HCID 1567	—
Reactant	11-(4S)-[2-(iodomethyldimethylsilanyl)-ethyl]-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione	HCID 57659383	—
Product	(4S)-4-ethyl-4-hydroxy-11-{2-[(2-hydroxy-ethylsulfanylmethyl)-dimethyl-silanyl]-ethyl}-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione	HCID 25261567	—

Reaction Steps

Prepared according to Procedure F using Compound 4 and 2-mercaptoethanol, the crude product was purified on a silica gel column using 3% ethanol in dichloromethane to obtain the pure product in 83% yields.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07687496B2
Source dataset	uspto-grants-2010_03
ORD ID	ord-1e88e6c4097d4fbca29f36b2f1922b8c
Source note	uspto-grants-2010_03