Benzyl Alcohol → HCID 68530198, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Compound 51 (1.21 g, 2 mmol), 4-dimethylaminopyridine (244 mg, 2 mmol) and pyridine (1.62 mL, 20 mmol) in dichloromethane (20 mL) at −10° C. was added phosgene (20% in toluene, 2.10 mL, 4 mmol) dropwise. The resulting mixture was stirred for 15 minutes at −10° C. Benzyl alcohol (0.83 mL, 8 mmol) was added and the resulting mixture was stirred at 21° C. for 2 hours. The reaction was quenched with saturated sodium bicarbonate solution, and aqueous layer was extracted with dichloromethane. The combined organic layers were dried over sodium sulfate and concentrated to afford yellow oil, which was chromatographed to give the desired product (Yield: 47%).

Provenance & Evidence