Cyclobutanecarbonyl chloride → HCID 68530168, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Compound 53 (70 mg, 0.11 mmol), 4-dimethylaminopyridine (27 mg, 0.22 mmol), and cyclobutanecarbonyl chloride (26 mg, 0.22 mmol) in 2.0 mL of dichloromethane was stirred at 21° C. for 5 hours. The reaction was quenched with saturated sodium bicarbonate solution, and aqueous layer was extracted with dichloromethane. The combined organic layers were dried over sodium sulfate and concentrated to afford a crude product, which was chromatographed to give the desired product.

Provenance & Evidence