反应详情

A stirring solution of (1R,2S,5R)-2-((S)-3-(benzyloxycarbonylamino)-2-oxopyrrolidin-1-yl)-5-(isopropyl(methyl)amino)cyclohexanecarboxylic acid (15.0 g, 0.0348 mol) in 1,4-dioxane (200 ml) was charged with N-methylmorpholine (5.26 g, 1.5 eq) and DPPA (14.3 g, 1.5 eq) at 0° C. The mixture was stirred at room temperature for 2 h. The mixture was charged with 2-(trimethylsilyl)ethanol (6.16 g, 1.5 eq) and then stirred for 2.5 h at 85° C. under the protection of nitrogen. The reaction was cooled to room temperature and the solvent was removed under reduced pressure. The resulting residue was dissolved in ethyl acetate (250 ml) and washed with saturated NaHCO3 (3×80 ml) and brine (3×80 ml). The solution was dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The residue obtained was purified with silica gel column chromatography eluting with 1% and 2.5% of methanol in dichloromethane to give 2-(trimethylsilyl)ethyl (1R,2S,5R)-2-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-5-(isopropyl(methyl)amino)cyclohexylcarbamate (9.3 g, 49%). LC/MS found [M+H]+=547.

1. stirringstirred for 2.5 h at 85° C. under the protection of nitrogen
2. temperatureThe reaction was cooled to room temperature
3. customthe solvent was removed under reduced pressure
4. dissolutionThe resulting residue was dissolved in ethyl acetate (250 ml)
5. washwashed with saturated NaHCO3 (3×80 ml) and brine (3×80 ml)
6. dry with materialThe solution was dried over anhydrous Na2SO4
7. filtrationfiltered
8. concentrationconcentrated in vacuo
9. customThe residue obtained
10. customwas purified with silica gel column chromatography
11. washeluting with 1% and 2.5% of methanol in dichloromethane