HCID 86618154, compound → HCID 68567035, compound

Participants

Reaction Steps

To a mixture of benzyl (S)-1-((1S,2R,4R)-2-acetamido-4-(dimethylamino)cyclohexyl)-2-oxopyrrolidin-3-ylcarbamate (70 mg) and 10% Pd/C (30 mg of 50% wet catalyst) was added EtOAc (50 mL) and then the flask was evacuated and back-filled with hydrogen. The mixture was stirred under 1 atm H2 for 16 h and the catalyst was removed by filtration through Celite. The filtrate was concentrated in vacuo to give N-((1R,2S,5R)-2-((S)-3-amino-2-oxopyrrolidin-1-yl)-5-(dimethylamino)cyclohexyl)acetamide as a white solid (40 mg, 85% yield), which was taken on to the next step without further purification. LC/MS found [M+H]+=283.

Provenance & Evidence